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Certain skin conditions may require alternative approaches or represent contraindications

GLP-1 medications may not be suitable for individuals with: History of pancreatitis (not recommended per UK SmPCs) Severe gastrointestinal disease or gastroparesis (caution advised) Diabetic retinopathy, particularly for semaglutide (requires monitoring) Pregnancy, planning pregnancy, or breastfeeding (contraindicated

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N-number: RNA sequencing utilized N=12 for the IP group and N=24 for the IN group