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The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail

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And the breakdown process itself generates inflammatory byproducts that contribute to generalized soreness

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Additionally, one month of treatment doesn't allow sufficient time for metabolic adaptation to lower calorie intake or for your body to reprogram its fat storage preferences

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