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BMC Endocr Disord 17(1):5

The Obesity Drug That Rivals Surgery In the TRIUMPH-4 trial, retatrutide helped people with obesity lose an average of: 23.7% of their body weight when counting all participants, including those who discontinued treatment 28.7% weight loss among people who stayed on the highest dose throughout the 68-week study Dr Caroline Apovian from Brigham and Womens Hospital called the results incredible, noting that this is the first drug to show weight loss comparable to weight-loss surgery

[2] [9] By activating GLP-1 receptors, retatrutide is thought to enhance insulin secretion in a glucose-dependent manner, suppress glucagon release, and reduce appetite

The study design followed rigorous protocols