i haven't lost any weight on semaglutide My thoughts after 12 months Wegovy (and a loss of 88 lbs) : r/ Woman shares journey of weight

This is important because: It gives your body time to adjust to the new medication Starting at a low dose helps reduce the risk of severe gastrointestinal side effects that typically occur with high doses of the medication

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The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity), a phase 3 study involving 17,604 adults with overweight or obesity and pre-existing CVD but no diabetes, revealed that once-weekly subcutaneous semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% compared with placebo over a mean follow-up of 39.8 months, including cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke [48]

The slowing of gastric emptying is an intended pharmacological effect that contributes to the medication's efficacy in reducing postprandial glucose excursions and promoting satiety