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Diabetes Obes Metab 23:224250

pharmacologic management with fibrates, niacin, statins and -3 fatty acids has achieved variable, but, in general, limited success Targeting the lipolytic pathway by use of gene therapy, inhibitors and antisense oligonucleotides might provide effective treatment options for this disease Abstract This Review discusses new developments in understanding the basis of chylomicronaemiaa challenging metabolic disorder for which there is an unmet clinical need