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Low serum B12 typically means less holoTC is circulating, which can slow down the delivery of B12 to cells
Understanding these risk factors enables clinicians to identify potentially vulnerable individuals and implement appropriate monitoring strategies
Alternative pathways to G6PD-dependent NADPH production exist in most human cells but not in erythrocytes, and the lack of protein synthetic machinery deprives the erythrocyte of the opportunity to replace enzyme that has been lost
Commonly prescribed options include GLP-1 receptor agonists (GLP-1 RAs) such as Semaglutide with B-12 and Tirzepatide with B-12
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