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Although the precise mechanism corresponding to ROS generation related to PD is still unknown, in this review, we summarize the major sources of oxidative stress generated by the DA neurons, like DA metabolism, mitochondrial dysfunction, and neuroinflammation ( Figure 1 )

L-carnitine acts as a biochemical buffer, binding to these toxic acyl groups and shuttling them out of the mitochondria and into the bloodstream for excretiona process known as "fatty acid dumping." This detoxification process relieves the metabolic pressure on the mitochondria, allowing them to repair and function more efficiently

Folates are involved in DNA biosynthesis and mediating one-carbon metabolism by transferring one-carbon units from serine to glycine