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The VEGFR2-Akt-eNOS pathway increases blood vessel formation
Additionally, studies suggest benefits for fistula healing and anastomosis (surgical connection) integrity in the gastrointestinal tract
Elderly patients may be more sensitive to the medications effects and may require slower titration or lower maintenance doses, particularly if they have reduced renal function or are at higher risk for dehydration from gastrointestinal adverse effects
On the other hand, sensory nerve damage can also lead to increased sensitivity to touch
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