While it is generally well tolerated, some users report difficulty falling asleep or staying asleep, particularly early in treatment or after dose increases
A clinical study involving 564 adults (BMI 30-40 kg/m2, without T2DM) found that compared with orlistat (3120 mg, weight loss of 4.1 kg), LIR (subcutaneous administration of 1.2 mg/d, 1.8 mg/d, 2.4 mg/d or 3 mg/d) had an average weight loss of 4.8-7.2 kg, the two-year extended experiment of which also showed similar results (88, 89)
prescribing it for that purpose is off-label On cash pay, Wegovy pill is dramatically cheaper: $149$299/month vs $900$1,200/month for Rybelsus With insurance covering diabetes, Rybelsus can be as low as $25/month but that coverage doesnt extend to weight loss Whats common between oral Wegovy and Rybelsus Both medications are oral semaglutide tablets manufactured by Novo Nordisk
Wegovy-equivalent generics arrive later and at a higher projected price point