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The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)

Levocarnitine is sold as a nutritional supplement usually,it is thought to help burn fat and help with weight loss

These analyses were kept as sensitivity analyses due to the numerous assumptions required to inform changes in clinical parameters on intensification, and to avoid these unduly influencing cost-effectiveness outcomes in the base case analysis

HFpEF is characterized by the presence of different comorbidities such as type-2 diabetes mellitus (T2DM), visceral obesity and ageing, all contributing to systemic metabolic inflammation [7, 8]