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The current medications vary in mechanism and magnitude: Semaglutide (Ozempic) targets GLP-1 receptors - around 15% average weight loss Tirzepatide (Mounjaro) targets GLP-1 + GIP - around 20% weight loss, often better GI tolerance Retatrutide (Phase 3 Trials) targets three receptors around 24% weight loss in trials, with broader metabolic effects The real risk is muscle mass loss

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It is primarily indicated for the treatment of advanced stage non-small cell lung cancer that is metastatic, as well as advanced melanoma and kidney cancer

What can I expect when using Semaglutide GLP-1 for weight loss