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Oxidative stress Oxidative stress is a disbalance caused by excessive production of prooxidant substances such as ROS and RNS and/or the antioxidant systems working inefficiently (14, 24, 25)

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Instruct patients on the management of hypoglycemia [see Warnings and Precautions (5.3)]

Additionally, arachidonic acid-15-lipoxygenase (ALOX15) knockdown or treatment with the lipoxygenase inhibitor baicalein has shown protective effects against ischemic brain damage in murine models (5, 45)