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Pharmacol Ther (2022) 239:108277

[42] [43] These properties contribute to the depletion of cysteine from respiratory chain complexes, such as Complexes I and IV, [44] since reactive oxygen species (ROS) produced by the respiratory chain can react with the cysteine residues in these complexes, leading to dysfunctional proteins and potentially contributing to aging

Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy

Serious side effects are rare but can include pancreatitis or thyroid complications in patients with relevant history