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Clinical trials have shown positive results regarding the efficacy of AOD-9604 for weight loss in humans, with one study reporting an average loss of 2.6 kg over 12 weeks, compared to 0.8 kg in the placebo group

The results showed statistically significant but clinically modest weight loss (2kg average advantage over placebo at the 1mg oral dose over 23 weeks)

This deficiency can be caused by poor dietary consumption, a breakdown in the digestive process, or from taking certain medications that make it difficult to absorb B12 (such as antacids)

In the SURMOUNT-1 trial, tirzepatide produced average weight loss of 15-22.5% of body weight over 72 weeks depending on dose