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Manufacturing: A Peptide-Specific Bottleneck From a bioprocessing perspective, GLP-1 analogs present unique challenges due to their peptide nature: Peptide Stability: GLP-1 analogs are prone to degradation due to their sensitivity to temperate, pH and enzymatic activity

Polymorphisms and a rare missense mutation that impair CaMKK2 function are associated with bipolar disorder Whole exome sequencing and genetic association studies have uncovered a link between bipolar disorder and loss-of-function polymorphisms and mutations in human CAMKK2

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Plus, they can be expensive and require a prescription