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Substances with long half-lives that accumulate in tissues over time present different risk profiles than those rapidly cleared

This research explores a novel therapeutic avenue by targeting the brains renin-angiotensin system (RAS) and its interaction with the hepatocyte growth factor (HGF)/c-Met receptor system [2]

Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

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