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Neurobiol Aging 1988

FIGURE 6 10.1 Multiple proteins interact with cardiolipin to induce pore formation While several amyloidogenic proteins have been known to disrupt the plasma membrane through pore formation, recently there has been growing interest in the concept that pore formation in the mitochondrial membrane may be the primary factor that initiates neurodegenerative disease, as well as type II diabetes

For normally distributed data, Students t-test was used for two-group comparisons and one-way ANOVA with Tukeys post hoc test was used for multiple comparisons

Endogenous sources include intracellular sources of ROS, where mitochondria produce ROS due to leakage of electrons during the transport chain, activated neutrophils, macrophages, epithelial cells, and NADPH oxidases