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2363-C REDUCTION OF TGF- AND IMPROVEMENT OF FIBROSIS AFTER OPTIMIZATION OF FECAL MICROBIOTA TRANSPLANT WITH AN ENDOSCOPIC-PLACEMENT HYDROGEL IN A MURINE MODEL OF STEATOHEPATITIS WITH FIBROSIS Ramon Bartoli Sole 1,2 , Ignacio Iborra 3 , Maria Torner Sim 3 , Alba Ardevol Ribalta 3 , Helena Masnou 2,3 and Rosa Maria Morillas 1,2,3 , (1)Ciberehd, (2)Germans Trias I Pujol Research Institute (IGTP), (3)Hospital Germans Trias I Pujol Background: Gut microbiota dysbiosis has become a key factor in the development and progression of non-alcoholic steatohepatitis (NASH) by influencing the immune and metabolic systems and increasing gut mucosa permeability to bacterial products, which in turns, activates the secretion of proinflammatory and profibrotic cytokines
Stress conditions promoting instability and denaturation of proteins induce the release of HSF-1, which the activity is associated with the expression of HSP70 in the myocardium, skeletal muscle, and human leucocytes [76, 107]
Supplements help us enrich our diet, and intramuscular injection of vitamins helps bypass the digestive system and get the nutrients throughout the body more efficiently
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