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Prior to the targeted synthesis and study of these peptides, research into growth hormone modulation and metabolic signaling relied largely on less specific hormonal interventions and generalized secretagogues

Additionally, pre-existing conditions such as skin inflammation, allergic responses, or aging can enhance the permeability and internalization of MPs/NPs, increasing susceptibility to their toxic effects [44] (Table 1)

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When ingested orally, glutamine is partially hydrolyzed in the gastrointestinal tract, which leads to substantial inactivation of the compound