how does glp 1 make you lose weight GLP-1 Therapy Part 1: Setting Realistic Loss Expectations – Sarah Hormachea GLP-1 and Health: Beyond Weight

doi: 10.1097/TEN.0b013e3181a5875e 34 HilesRABawdonREPetrellaEM

Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users

Sleep disorders are common in type 2 diabetes and cause disturbances in the quantity, quality and timing of sleep and are associated with an increased risk of obesity and impairments in daytime functioning and glucose metabolism [114, 115]

Patients were randomized 1:1 to receive subcutaneous semaglutide 2.4 mg once weekly or placebo as an adjunct to standard-of-care therapy for CVD, such as cholesterol-modifying medications, antiplatelet therapies and antihypertensive agents