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The results presented by the authors revealed a significant improvement in CARS scores in patients receiving L-carnitine, this improvement was associated with an increase in total and free carnitine levels

Food and Drug Administration, the European Medicines Agency, or any other national regulator for any indication

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The activation of TFEB requires modification of a specific lysine residue in the translation initiation factor 5A (eIF-5A) generating what is called hypusine (derived from hy droxy pu trescine and ly sine ) which involves spermidine as outlined in the Polyamines in Protein Modification below