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Description

McMurray, J

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Studies have shown that cisplatin induces CAFs to secrete chemokine (CC motif) ligand 5 (CCL5), which inhibits cisplatin-induced tumor cell apoptosis by regulating the STAT3 and PI3K/Akt signaling pathways, thereby further promoting tumor cell resistance to cisplatin treatment [42]

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A reduction of glutathione (GSH) was strongly associated with sensitising cells to the pro-apoptotic effects of polyphenols when used in combination with doxorubicin or etoposide

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