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Mol Neurobiol 47:632644 Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, Giustetto M, Ferreira TA, Guiducci E, Dumas L, Ragozzino D (2011) Synaptic pruning by microglia is necessary for normal brain development
Overall, these SAR studies using the ternary complex structure including FBXO22, NSD2, and our next-generation NSD2 degrader, UNC10415667, revealed that UNC12149 is a more potent NSD2 degrader
The SAR studies uncovered evidence of C-3 hydroxyl groups as critical for facilitating bioactivity and pharmacokinetics through modifications (e.g., esterification with nitrogen heterocycles or glycosylation)
"We ask people to invest something real at the front door because the evaluation is the treatment decision," Dr
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