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However, their long-term efficacy on reproductive and metabolic outcomes remains controversial, and evidence strength is generally rated as moderate

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The guidance outlines five key recommendations relating to GLP-1RAs and GLP-1/GIPRAs and sedation or anaesthesia: All patients should be asked about the use of GLP-1RAs and GLP-1/GIPRAs before anaesthesia or sedation for surgical and endoscopic procedures and be involved in discussion and planning regarding the risk of aspiration

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