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Thats great for anti-aging and scar remodelingbut when you already have excess sebum production, heres what happens: Your skin starts producing new cells faster Those cells need to shed (exfoliate) to make room But your pores are already clogged with oil The increased cell debris + existing sebum = more congestion Result: deeper clogs, more inflammation, worse breakouts Its like trying to renovate a house while the plumbing is actively overflowing

In: Protein Allostery in Drug Discovery (eds Zhang, J., Nussinov, R.) (Springer Singapore, 2019)

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Second, a 13-amino acid extension is added to the N-terminus of the molecule