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Notably, histological analysis at this time point revealed no significant hepatocyte damage, suggesting that the rapid decrease in hepsin protein levels may primarily result from the activation and subsequent degradation of the hepsin serine protease in response to APAP-induced hepatotoxicity

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Ariceta G, Camacho JA, Fernandez-Obispo M, Fernandez-Polo A, Gamez J, Garcia-Villoria J, Lara Monteczuma E, Leyes P, Martin-Begue N, Oppenheimer F, Perello M, Morell GP, Torra R, Santandreu AV, Guell A, Grupo T-CiS.bcn (2015) Cystinosis in adult and adolescent patients: recommendations for the comprehensive care of cystinosis