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MTs in late-stage MASLD and hepatocellular carcinoma Furthermore, it has been shown that MASH can lead to a significant percentage of cirrhosis cases that cannot be attributed to a specific cause (idiopathic or cryptogenic)

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An RCT in patients receiving cisplatin chemotherapy found that NAC (1,200 mg/day) significantly reduced nephrotoxicity and ototoxicity without reducing antitumor efficacy (Riga et al., Am J Clin Oncol, 2013) [77]

Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency