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however, clinical success is a subjective assessment and dependent on individual treatment targets for each participant

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Across registered trials, retatrutide has produced the largest weight reductions reported for an incretin-class compound roughly 24% at 12 mg over 48 weeks in phase 2 [1], extended to about 2829% over 6880 weeks in the phase 3 TRIUMPH topline [5], alongside lower HbA1c in type 2 diabetes and large falls in liver-fat content

GI losses, the use of diuretics, hemorrhages, and endocrine impairments such as adrenal insufficiency, ACTH (adrenocorticotropic hormone) deficit, or severe hypothyroidism are common causes of low sodium levels