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They should never be taken within six hours of bedtime due to caffeines half-life of five to seven hours

6.6.1 Microbiota modulation by Chinese herbal formulas Chinese herbal preparations may exert antidepressant-like effects by modulating neurotransmitter levels, SCFAs, BDNF, the kynurenine pathway, and pro-inflammatory cytokines (Zhu et al., 2019

People with cardiovascular risk factors see meaningful improvements

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