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GLP-1 receptor agonists such as Mounjaro and Wegovy produce several effects that support weight loss: Reduced appetite and fewer food cravings Slower gastric emptying, meaning you feel full sooner and stay satisfied longer after meals Improved blood sugar regulation, which reduces energy spikes and dips that trigger overeating Reduced interest in high-calorie, highly processed foods for many patients Mounjaro (tirzepatide) also activates the GIP receptor, making it a dual agonist

The conclusion in the prescribing information is unambiguous: "similar exposure" is achieved regardless of which approved site is used

Amgen was essentially saying: we will sell at one price if you want transparency and another price if you want to play the PBM game

Its primary approved indication in the United States is the reduction of excess abdominal fat in HIV-positive adults with lipodystrophy, a condition characterised by abnormal fat redistribution often associated with antiretroviral therapy