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Stinging or burning sensation: First few usages or when applied to compromised skin (post-exfoliation or damaged barrier)

A straight diagonal line or FIC index = 1 indicates a clear additive effect between the two drugs, while a concave curve below the diagonal of the graph denotes a synergistic effect between the drugs

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(Wegovy, Mounjaro & the New Pill, 2026) Updated 22/06/26 Based on the available clinical evidence, Mounjaro (tirzepatide) and Wegovy (semaglutide) are both well tolerated, but most people find Mounjaro causes fewer gastrointestinal side effects at comparable doses, with lower rates of nausea and a higher likelihood of completing treatment