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There lies a narrow physiochemical window for the drug to effectively pass the stratum corneum which includes low melting point, low molecular weight of 600 Da, and water/octanol partition coefficient in the range of 13 [216]

Although research has demonstrated the therapeutic potential of Chinese medicine in treating depression, inconsistencies in experimental design, sample selection, and data analysis methods have led to significant heterogeneity in results

While it can be found as part of the normal microflora of the gastrointestinal tract, it can also cause severe diarrhoea in people who have recently taken antibiotics

Meurot C, Jacques C, Martin C, Sudre L, Breton J, Rattenbach R, Bismuth K, Berenbaum F