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In a post-hoc analysis of the published SURPASS trials, the change in systolic blood pressure was greater for tirzepatide versus the comparators of the trials (tirzepatide 5 mg: -5.1 to -1.3 mmHg, tirzepatide 10 mg: -6.5 to -1.7 mmHg, tirzepatide 15 mg: -11.5 to -3.1 mmHg) [65]
An interesting question is whether one of these hormones contributes more to tirzepatides effects than the other
GLP-1 medicines are used for some tamariki and rangatahi with diabetes
This is not an endorsement of the practice but more of a reflection of the FDA's tolerance for genuine patient-specific compounding at de minimis scale
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