Newborn screening
These results support the notion that curcumin acts as an agonist for GPR55 and suggest that curcumin may exert cannabinoid-like activity through activation of cannabinoid receptors
Disclosure of interest: Nothing to disclose E-Posters - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.07 - SMALL VESSEL DISEASE P2397 - ESOC25-1825 GENOMICS OF NEW AUTOMATED DIFFUSION IMAGING MARKER SHEDS LIGHT INTO LIFESPAN DETERMINANTS OF CEREBRAL SMALL VESSEL DISEASE Yasaman Saba 1 , Hideaki Suzuki 2 , Pauline Maillard 3 , Michelle Luciano 4 , Ilana Caro 1 , Marco Duering 5 , Joanna Wardlaw 6 , Sudha Seshadri 7 , Lenore Launer 8 , Helena Schmidt 9 , Vilmundur Gudnason 10 , Paul Matthews 11 , Monique Breteler 12 , Aniket Mishra 1 , Stphanie Debette 1 1 University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France, 2 Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan, 3 Department of Neurology, University of California, Davies, United States, 4 Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom, 5 Medical Image Analysis Center (MIAC AG) and Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 6 UK Dementia Research Institute Centre, University of Edinburgh, Edinburgh, Edinburgh, United Kingdom, 7 Glenn Biggs Institute for Alzheimers and Neurodegenerative Diseases, University of Texas Health Sciences Center, St Antonio, United States, 8 Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Baltimore, United States, 9 Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria, 10 Icelandic Heart Association, Kopavogur, Reykjavik, Iceland, 11 UK Dementia Research Institute, London, London, United Kingdom, 12 Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Background and Aims: Peak width of skeletonized mean diffusivity (PSMD) has been proposed as a novel diffusion imaging marker for cerebral small vessel disease (cSVD), a leading cause of stroke and dementia with no mechanism-based treatments
Nevertheless, recent advances in understanding the molecular mechanisms, regulatory factors of GLP-1 secretion, signaling pathways, and transcription factors that are effective in endocrine cell differentiation may pave the way for the development of effective applicable medications that can increase GLP-1 secretion and improve L-cell differentiation
