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Emerging studies using CSF and advanced neuroimaging techniques, such as brain magnetic resonance spectroscopy (MRS) are beginning to uncover neurobiological changes that may further elucidate disease mechanisms

Sleep optimization is particularly important, as sleep deprivation elevates evening cortisol and disrupts normal diurnal rhythm

Amongst people with HF, up to 50% are estimated to have type 2 diabetes and, vice versa, around 20% of the over 500 million people living with type 2 diabetes have been shown to have comorbid HF (ClinicalTrials.gov IDs NCT04916470 and NCT04788511), it may be relevant to consider obesity-related HFpEF as a specific (sub)phenotype, whether coexisting with type 2 diabetes or not

The peptides gentle, consistent mechanism makes it ideal for pairing with more aggressive weight loss agents