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Other therapeutic approaches targeting fibroblast ferroptosis have also emerged: the in vitro and in vivo experiments demonstrate that platelet-rich plasma (PRP) promotes healing of type 2 diabetic mouse ulcers by inhibiting fibroblast ferroptosis and improving functional impairment [78, 80], providing a new strategy for diabetic ulcer treatment

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These ligands interact with several receptor proteins including AT 1 , AT 2 , AT 4 , and Mas distributed within the central and peripheral nervous systems as well as local RASs in several organs

One such example is Pseudolaric acid B (PAB), a naturally occurring diterpene acid extracted from Kaempferia roots and bark