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The authors also surmised that CoQ 10 supplementation decreased pro-inflammatory cytokines and inflammatory markers in the elderly with low CoQ 10 levels (Fan et al., Metabolic diseases, characterized by chronic, low grade inflammation, respond well to CoQ 10 supplementation with significant decrease in TNF- plasma levels without having an effect on C-reactive protein and IL-6 production (Zhai et al., 2017)