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Some doctors and specialists may also consider lower BMI thresholds when patients have weight-related conditions, reflecting evidence that Asian populations tend to develop obesity-related metabolic complications including Type 2 diabetes and cardiovascular disease at lower BMI levels than Western populations

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In addition, experimental medical blockade of NPY signaling with the Y5-receptor antagonist MK-0577 failed to cause any significant weight loss in a 1-year clinical trial (87)

Ozempic is FDA-approved for the control of blood sugar in type 2 diabetes and decreasing the risk of major cardiovascular events, including death, in those with type 2 diabetes