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This may also be consistent with impaired mitochondrial biogenesis as described in circulating lymphocytes in chronic inflammatory conditions (45) and in patients with idiopathic ME/CFS ( Also, we detected a reduction in serine concentration, which was inversely associated with depression and anxiety scores in LC patients

It does not show the same cardiovascular outcome data

In addition, captopril significantly increases the concentration of 5-HT and 5-HIAA in the parabrachial lateral nucleus (169)

In mice with myocardial hypertrophy induced by angiotensin II (ANGII), the expression of SLC7A11 decreased, and the inhibitory effect of SLC7A11 increased the contents of PTGS2, MDA and ROS, which aggravated cardiomyocyte hypertrophy