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Depression and reduced libido

As discussed in more detail in a white paper in preparation (24), it enters cell membranes as a lipophilic anion where it acts as a proton shunt (11), dissipating pH gradients across a range of host cellular-organelle membranes, including mitochondria, endosomes and lysosomes, and even the Golgi

145,146,147 Research involving mice lacking OGG1 validated its ability to eliminate 8-oxoguanine (8oxoG) damage

In distal tubular injury, leakage of urinary regulatory proteins into the interstitial space activates dendritic cells through TLR4 and NLRP3 inflammasomes, initiating an immune response [323, 324]