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Description

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We restored the stability of a reprogrammed BoNT/E protease, and distinct sequence-redesigned BoNT proteases each consistently outperformed the natural protease at various new substrate selections, in all evolutions reaching high-activity mutation space that is non-functional in the undesigned natural enzyme

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Clinical Applications The compounds and methods disclosed herein can be used for both medical applications and animal husbandry or veterinary applications

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