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Preventing Future Breaks While some breaks are unavoidable, strategies exist to minimize disruptions to treatment

The Beyond-Use Date is determined by the specific date the medication was compounded and the ingredients used in that specific batch

First approved as the iPLEDGE Program in 2005, then as the iPLEDGE REMS (Risk Evaluation and Mitigation Strategy) in 2010, it established a centralized system for prescribers, pharmacies, and patients to manage patient risk, regardless of which isotretinoin product is being used

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