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beyond the plasma membrane (FSP1) and mitochondria (DHODH), the specific antioxidant mechanisms in organelles such as the endoplasmic reticulum (a major site of lipid synthesis) and peroxisomes (involved in lipid oxidation) are poorly defined, and their crosstalk with cytoplasmic SOD/CAT remains elusive

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But they worry that too few children return for the fourth and final shot, or booster dose, that the World Health Organization says is essential to prolong immunity, as it is given months after the other doses

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