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However, a clinical trial utilizing nivolumab, a PD-1 inhibitor, in patients with metastatic castration-resistant prostate cancer (mCRPC) failed to demonstrate notable objective response rates (Topalian et al., 2012)

Nian Liu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In preclinical models this combination showed an additive effect

We discuss the synergistic vicious cycle between -syn aggregation and iron dysregulation, which amplifies lipid peroxidation and ferroptotic cell death