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Int J Mol Sci 22(9):4642

GLP-1 receptors are present in various tissues beyond the pancreas, including the cardiovascular and nervous systems

Additionally, a 1-year training study in 155 older women demonstrated that not only was a single day of high intensity RT (2 sets of 6-8 repetitions at 70%85% of 1RM) per week sufficient to improve memory at the cessation of the study compared to pre-training, but these cognitive benefits persisted for 1 year after training compared to balance-and-toning controls (Mcleod et al., 2024), but evidence does support that intensity mediates exercise-related neurogenesis and neuroplasticity in interval and aerobic exercise models (Marko et al., 2022

Sympathetic nervous system effects may contribute to heart rate changes