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doi: 10.3390/pharmaceutics15020533 [DOI] [PMC free article] [PubMed] [Google Scholar] 133.Salem HF, Kharshoum RM, Abou-Taleb HA, Naguib DM

Despite reperfusion reestablishing oxygenation, it paradoxically exacerbates the injury by promoting reactive oxygen species production and encouraging pro-inflammatory neutrophils to infiltrate the ischemic tissues, thereby amplifying the ischemic damage [49] (Fig