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10.1038/s41586-019-1707-0 33 DongC.HeZ.LiaoW.JiangQ.SongC.SongQ.et al (2025)

The ARC within the forebrain, the VTA within the midbrain, and the NTS within the hindbrain are three main regions responsive to direct leptin stimulation [51, 61]

Organelle clearance, primarily the expulsion of mitochondria in erythroblasts or reticulocytes, is accompanied by the removal of the mitochondrial apoptosis-associated machinery

This application originally an incidental finding in early tanning research has been extensively studied and led directly to the development of PT-141 (Bremelanotide) as a selective MC4R-targeting compound