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Some providers will prescribe below BMI 27 based on clinical judgment

Lingvay, J

As more non-weight indications emerge, including potential applications for addiction, Alzheimer disease, fatty liver disease, and chronic kidney disease, the relevance of BMI as the primary gatekeeper will diminish

Yet GLP-1 receptors are not expressed on liver cells, suggesting that the drugs have an indirect effect: There are no GLP-1 receptors expressed in hepatocytes