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10.3390/molecules25184196 [DOI] [PMC free article] [PubMed] [Google Scholar] Ogata F

Given the intricate interplay between different cellular components, organelles, and pathways that regulate ferroptosis [107], it is imperative to consider the broader cellular context when evaluating ferroptosis triggers, modulators, and potential therapeutic interventions

Similar findings were reported in prospective clinical studies.68,69 A large multicenter RCT (n=194), however, found no significant differences with placebo.70 A meta-analysis of the above findings for a total of 480 patients showed a favorable effect on facial appearance.70 Multiple oral antioxidants and anti-inflammatory agents, such as vitamins A, C, D, and E, green tea polyphenols, niacinamide, and trace elements such as zinc may help mitigate signs of skin aging

Soluble Abeta oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors