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A portion of the cause can be traced to the decline in the brain's ability to produce neurotransmitters, which is intimately related to the reduced availability of corresponding amino acid precursors, such as methionine, tyrosine (required for the synthesis of dopamine and norepinephrine), and tryptophan (required for neurotransmitter) (Aquilani et al

Then know this may be temporary as your body adjusts

One well-documented interaction is with certain anti-epileptic drugs: high-dose pyridoxine may reduce the plasma levels of phenytoin and phenobarbital by enhancing their hepatic metabolism, potentially diminishing their anticonvulsant efficacy